Rega Institute - Department of Microbiology and Immunology
Chairman: Prof. Dr. Tassos Economou
We mainly focus on two bacterial protein export pathways: a. The Sec pathway (ubiquitous and essential throughout life). and b. The Type III secretion (T3S) pathway (essential weapon for several Gram negative pathogens). Understanding protein trafficking helps us understand debilitating diseases such as cystic fibrosis that result from defective protein targeting. Other applications that stem from our basic research include novel antibacterials and vaccines, production of recombinant biopharmaceuticals, biosensors and bionanotechnology and combating biofilms.
Gouridis, G., Karamanou, S., Sardis, M.-F., Schärer, M.A., Capitani, G. and Economou, A. (2013) Quaternary dynamics of the SecA motor drive translocase catalysis.
Molecular Cell 52 (in press)
Papanastasiou, M., Orfanoudaki, G., Koukaki, M., Kountourakis, N., Sardis, M.F., Aivaliotis, M., Karamanou, S. and Economou, A. (2013) The Escherichia coli Peripheral Inner Membrane Proteome. Molecular and Cellular Proteomics 12, 599-610
Chen, L., Balabanidou, V., Remeta, D.P. Minetti, C.A.S.A., Portaliou, A.G., Economou, A. and Kalodimos, C.G. (2011) Structural instability tuning as a regulatory mechanism in protein-protein interactions. Molecular Cell 44, 734-44.
Gouridis, G., Karamanou, S., Gelis, I., Kalodimos, C.G. and Economou, A (2009) Signal peptides are allosteric activators of the protein translocase. Nature 462, 363-36.
Gelis, I., Bonvin, A.M.J.J., Keramisanou , D.,Koukaki, M., Gouridis, G., Karamanou, S., Economou , A. and Kalodimos , C.G. (2007) Structural Basis for Signal-Sequence Recognition by the Translocase Motor SecA as Determined by NMR. Cell 131, 756-769.
Karamanou, S., Gouridis, G., Papanikou, E., Sianidis, G., Gelis, I., Keramisanou, D., Vrontou, E., Kalodimos , C.G. and Economou, A. (2007) Preprotein-controlled catalysis in the helicase motor of SecA. EMBO Journal 26, 2904-2911.