You are here: virology and chemotherapy Research group Prof. L. Naesens Contact Lieve Naesens

Lieve Naesens
Lieve Naesens
Minderbroedersstraat 10 blok x - box 1030
3000 Leuven
Belgium

tel: +32163 37345 or +32163 37341
fax: +32163 37340

Publications
Articles in international reviewed journals (153)

Bereczki I., Kicsák M., Dobray L., Borbás A., Batta G., Kéki S., Nikodém É., Ostorházi E., Rozgonyi F., Vanderlinden E., Naesens L., Herczegh P. 2014. Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: synthesis and antiviral studies. Bioorganic & medicinal chemistry letters. nr.24 , pp. 3251-4 , ISSN 1464-3405

Carcelli M., Rogolino D., Sechi M., Rispoli G., Fisicaro E., Compari C., Grandi N., Corona A., Tramontano E., Pannecouque C., Naesens L. 2014. Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors. European journal of medicinal chemistry. nr.83 , pp. 594-600 , ISSN 1768-3254

Rey-Carrizo M., Barniol-Xicota M., Ma C., Frigolé-Vivas M., Torres E., Naesens L., Llabrés S., Juárez-Jiménez J., Luque F., DeGrado W., Lamb R., Pinto L., Vázquez S. 2014. Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus. Journal of medicinal chemistry. nr.57 , pp. 5738-47 , ISSN 1520-4804

Torres E., Leiva R., Gazzarrini S., Rey-Carrizo M., Frigolé-Vivas M., Moroni A., Naesens L., Vázquez S. 2014. Azapropellanes with anti-influenza a virus activity. ACS medicinal chemistry letters. nr.5 , pp. 831-6 , ISSN 1948-5875

Tollas S., Bereczki I., Borbás A., Batta G., Vanderlinden E., Naesens L., Herczegh P. 2014. Synthesis of a cluster-forming sialylthio-d-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase. Bioorganic & Medicinal Chemistry Letters. Pergamon Press nr.24 , pp. 2420-3 , ISSN 0960-894X

Vanderlinden E., Naesens L. 2014. Emerging antiviral strategies to interfere with influenza virus entry. Medicinal Research Reviews. Wiley nr.34 , pp. 301-39 , ISSN 0198-6325

Carcelli M., Rogolino D., Bacchi A., Rispoli G., Fisicaro E., Compari C., Sechi M., Stevaert A., Naesens L. 2014. Metal-chelating 2-hydroxyphenyl amide pharmacophore for inhibition of influenza virus endonuclease. Molecular Pharmaceutics. American Chemical Society nr.11 , pp. 304-316 , ISSN 1543-8384

Coen N., Duraffour S., Naesens L., Krecmerová M., van den Oord J., Snoeck R., Andrei G. 2013. Evaluation of novel acyclic nucleoside phosphonates against human and animal γ-herpesviruses revealed an altered metabolism of cyclic prodrugs upon EBV reactivation in P3HR-1 cells. Journal of Virology. American Society for Microbiology (ASM) nr.87 , pp. 12422-12432 , ISSN 0022-538X

Rey-Carrizo M., Torres E., Ma C., Barniol-Xicota M., Wang J., Wu Y., Naesens L., Degrado W., Lamb R., Pinto L., Vázquez S. 2013. 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. Journal of Medicinal Chemistry. ACS Publications nr.56 , pp. 9265-74 , ISSN 0022-2623

Naesens L., Guddat L., Keough D., van Kuilenburg A., Meijer J., Vande Voorde J., Balzarini J. 2013. Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Molecular Pharmacology. American Society for Pharmacology and Experimental Therapeutics nr.84 , pp. 615-629 , ISSN 0026-895X

Stevaert A., Dallocchio R., Dessì A., Pala N., Rogolino D., Sechi M., Naesens L. 2013. Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease. Journal of Virology. American Society for Microbiology (ASM) nr.87 , pp. 10524-10538 , ISSN 0022-538X

Torres E., Duque M., Vanderlinden E., Ma C., Pinto L., Camps P., Froeyen M., Vázquez S., Naesens L. 2013. Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds. Antiviral Research. Elsevier/North-Holland nr.99 , pp. 281-91 , ISSN 0166-3542

Keough D., Hocková D., Rejman D., Spaček P., Vrbková S., Krečmerová M., Eng W., Jans H., West N., Naesens L., Jersey J., Guddat L. 2013. Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry. ACS Publications nr.56 , pp. 6967-84 , ISSN 0022-2623

De Schutter T., Andrei G., Topalis D., Naesens L., Snoeck R. 2013. Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage. BMC Medical Genomics. BioMed Central Ltd. nr.6 , pp. 18- , ISSN 1755-8794

Zoidis G., Naesens L., De Clercq E. 2013. An intriguing and facile one-pot catalytic synthesis of N-alkylated lactams. Monatshefte für Chemie. Springer-Verlag Wien (WIEN) nr.144 , pp. 515-521 , ISSN 0026-9247

Keough D., Spaček P., Hocková D., Tichý T., Vrbková S., Slavětínská L., Janeba Z., Naesens L., Edstein M., Chavchich M., Wang T., Jersey J., Guddat L. 2013. Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry. ACS Publications nr.56 , pp. 2513-2526 , ISSN 0022-2623

Meneghesso S., Vanderlinden E., Brancale A., Balzarini J., Naesens L., McGuigan C. 2013. Synthesis and Biological Evaluation of Purine 2'-Fluoro-2'-deoxyriboside ProTides as Anti-influenza Virus Agents. ChemMedChem. Wiley - V C H Verlag GmbH & Co. KGaA nr.8 , pp. 415-425 , ISSN 1860-7179

De Schutter T., Andrei G., Topalis D., Duraffour S., Mitera T., Naesens L., van den Oord J., Matthys P., Snoeck R. 2013. Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice. Cancer Letters. Elsevier nr.329 , pp. 137-145 , ISSN 0304-3835

Sipos A., Máté G., Rőth E., Borbás A., Batta G., Bereczki I., Kéki S., Jóna I., Ostorházi E., Rozgonyi F., Vanderlinden E., Naesens L., Herczegh P. 2012. Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities. European Journal of Medicinal Chemistry. nr.58 , pp. 361-367 , ISSN 0223-5234

Sipos A., Török Z., Rőth E., Kiss-Szikszai A., Batta G., Bereczki I., Fejes Z., Borbás A., Ostorházi E., Rozgonyi F., Naesens L., Herczegh P. 2012. Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities. Bioorganic & Medicinal Chemistry Letters. Pergamon Press nr.22 , pp. 7092-7096 , ISSN 0960-894X

Vanderlinden E., Vanstreels E., Boons E., Ter Veer W., Huckriede A., Daelemans D., Van Lommel A., Roth E., Sztaricskai F., Herczegh P., Naesens L. 2012. Intracytoplasmic trapping of influenza virus by a lipophilic derivative of aglycoristocetin. Journal of Virology. American Society for Microbiology (ASM) nr.86 , pp. 9416-9431 , ISSN 0022-538X

Li Z., Zhan P., Naesens L., Vanderlinden E., Liu A., Du G., De Clercq E., Liu X. 2012. Synthesis and preliminary biologic evaluation of 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles as a novel class of influenza virus A inhibitors. Chemical Biology & Drug Design. Blackwell Munksgaard nr.79 , pp. 1018-1024 , ISSN 1747-0277

Zhan P., Wang L., Liu H., Chen X., Jiang X., Zhang Q., Liu X., Pannecouque C., Naesens L., De Clercq E., Liu A., Du G. 2012. Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents. Archives of Pharmacal Research. The Society nr.35 , pp. 975-986 , ISSN 0253-6269

Lenaerts L., van Dam W., Persoons L., Naesens L. 2012. Interaction between mouse adenovirus type 1 and cell surface heparan sulfate proteoglycans. PLoS One. Public Library of Sciene nr.7 , ISSN 1932-6203

Meneghesso S., Vanderlinden E., Stevaert A., McGuigan C., Balzarini J., Naesens L. 2012. Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus. Antiviral Research. Elsevier/North-Holland nr.94 , pp. 35-43 , ISSN 0166-3542

Torres E., Duque M., López-Querol M., Taylor M., Naesens L., Pinto L., Sureda F., Kelly J., Vázquez S. 2012. Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. Bioorganic & Medicinal Chemistry. Pergamon nr.20 , pp. 942-948 , ISSN 0968-0896

Mironiuk-Puchalska E., Koszytkowska-Stawińska M., Sas W., De Clercq E., Naesens L. 2012. Synthesis of Novel AZA-Analogues of Tiazofurin with 2-[5,5-bis(Hydroxymethyl)Pyrrolidin-2-yl] Framework as Sugar Mimic. Nucleosides, Nucleotides & Nucleic Acids. Marcel Dekker nr.31 , pp. 72-84 , ISSN 1525-7770

Goktas F., Vanderlinden E., Naesens L., Cesur N., Cesur Z. 2012. Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives. Bioorganic & Medicinal Chemistry. Pergamon (OXFORD) nr.20 , pp. 7155-7159 , ISSN 0968-0896

Yu M., Liu A., Du G., Naesens L., Vanderlinden E., De Clercq E., Liu X. 2011. Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents. Chemical Biology & Drug Design. Blackwell Munksgaard nr.78 , pp. 596-602 , ISSN 1747-0277

Jersey J., Holý A., Hocková D., Naesens L., Keough D., Guddat L. 2011. 6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry. Bentham Science Publishers nr.11 , pp. 2085-2102 , ISSN 1568-0266

Deterding K., Naesens L., Buti M., Janssen H., Kirschner J., Guerrero A., Reijnders J., Neyts J., Zoulim F., Wedemeyer H. 2011. Adefovir serum levels do not differ between responders and nonresponders. Journal of Viral Hepatitis. Blackwell Science nr.18 , pp. E175-E178 , ISSN 1352-0504

Duque M., Ma C., Torres E., Wang J., Naesens L., Juarez-Jiménez J., Camps P., Luque F., DeGrado W., Lamb R., Pinto L., Vazquez S. 2011. Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus. Journal of Medicinal Chemistry. ACS Publications nr.54 , pp. 2646-2657 , ISSN 0022-2623

Valverde E., Torres E., Guardiola S., Naesens L., Vázquez S. 2011. Synthesis and antiviral evaluation of bisnoradamantane sulfites and related compounds. Medicinal Chemistry. Bentham science publ ltd. nr.7 , pp. 135-140 , ISSN 1573-4064

Torres E., Duque M., Camps P., Naesens L., Calvet T., Font-Bardia M., Vázquez S. 2010. Polycyclic N-benzamido imides with potent activity against vaccinia virus. ChemMedChem. Wiley - V C H Verlag GmbH & Co. KGaA nr.5 , pp. 2072-2078 , ISSN 1860-7179

Zoidis G., Kolocouris N., Kelly J., Prathalingam S., Naesens L., De Clercq E. 2010. Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines. European Journal of Medicinal Chemistry. nr.45 , pp. 5022-5030 , ISSN 0223-5234

Krecmerová M., Holý A., Andrei G., Pomeisl K., Tichý T., Brehová P., Masojídková M., Dracínský M., Pohl R., Laflamme G., Naesens L., Hui H., Cihlar T., Neyts J., De Clercq E., Balzarini J., Snoeck R. 2010. Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. Journal of Medicinal Chemistry. ACS Publications nr.53 , pp. 6825-37 , ISSN 0022-2623

Keough D., Hocková D., Krecmerová M., Cesnek M., Holý A., Naesens L., Brereton I., Winzor D., Jersey J., Guddat L. 2010. Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology. Elsevier/North-Holland Biomedical Press nr.173 , pp. 165-9 , ISSN 0166-6851

Marchal A., Nogueras M., Sanchez A., Low J., Naesens L., De Clercq E., Melguizo M. 2010. Alkoxy-5-nitrosopyrimidines: useful building block for the generation of biologically active compounds. European Journal of Organic Chemistry. Wiley-VCH nr.2010 , pp. 3823-30 , ISSN 1434-193X

Bonnafous P., Verbelen M., Petrella S., Deback C., Gautheret-Dejean A., Boutolleau D., Naesens L., Agut H. 2010. Conservation of HHV-6 DNA polymerase processivity factor sequence and predicted structure suggests it as a target for antiviral development. Antiviral Research. Elsevier/North-Holland nr.86 , pp. 316-9 , ISSN 0166-3542

Vanderlinden E., Göktas F., Cesur Z., Froeyen M., Reed M., Russell C., Cesur N., Naesens L. 2010. Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin. Journal of Virology. American Society for Microbiology (ASM) nr.84 , pp. 4277-88 , ISSN 0022-538X

Lannang A., Louh G., Biloa B., Komguem J., Mbazoa C., Sondengam B., Naesens L., Pannecouque C., De Clercq E., Sayed El Ashry E. 2010. Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii. Planta Medica. Georg Thieme Verlag nr.76 , pp. 708-12 , ISSN 0032-0943

Pintér G., Bereczki I., Batta G., Otvös R., Sztaricskai F., Roth E., Ostorházi E., Rozgonyi F., Naesens L., Szarvas M., Boda Z., Herczegh P. 2010. Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity. Bioorganic & Medicinal Chemistry Letters. Pergamon Press nr.20 , pp. 2713-7 , ISSN 0960-894X

Derudas M., Brancale A., Naesens L., Neyts J., Balzarini J., McGuigan C. 2010. Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin. Bioorganic & Medicinal Chemistry. Pergamon nr.18 , pp. 2748-2755 , ISSN 0968-0896

Pintér G., Batta G., Kéki S., Mándi A., Komáromi I., Takács-Novák K., Sztaricskai F., Röth E., Ostorházi E., Rozgonyi F., Naesens L., Herczegh P. 2009. Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study. Journal of Medicinal Chemistry. ACS Publications nr.52 , pp. 6053-6061 , ISSN 0022-2623

Keough D., Hocková D., Holý A., Naesens L., Skinner-Adams T., Jersey J., Guddat L. 2009. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. Journal of Medicinal Chemistry. ACS Publications nr.52 , pp. 4391-4399 , ISSN 0022-2623

Duque M., Camps P., Profire L., Montaner S., Vázquez S., Sureda F., Mallol J., López-Querol M., Naesens L., De Clercq E., Prathalingam S., Kelly J. 2009. Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines. Bioorganic & Medicinal Chemistry. Pergamon nr.17 , pp. 3198-3206 , ISSN 0968-0896

Naesens L., Vanderlinden E., Roth E., Jeko J., Andrei G., Snoeck R., Pannecouque C., Illyés E., Batta G., Herczegh P., Sztaricskai F. 2009. Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains. Antiviral Research. Elsevier/North-Holland nr.82 , pp. 89-94 , ISSN 0166-3542

Rajic Z., Butula I., Zorc B., Pavelic S., Hock K., Pavelic K., Naesens L., De Clercq E., Balzarini J., Przyborowska M., Ossowski T., Mintas M. 2009. Cytostatic and antiviral activity evaluations of hydroxamic derivatives of some non-steroidal anti-inflammatory drugs. Chemical Biology & Drug Design. Blackwell Munksgaard nr.73 , pp. 328-338 , ISSN 1747-0277

Zoidis G., Kolocouris N., Naesens L., De Clercq E. 2009. Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity. Bioorganic & Medicinal Chemistry. Pergamon nr.17 , pp. 1534-1541 , ISSN 0968-0896

Lenaerts L., McVey J., Baker A., Denby L., Nicklin S., Verbeken E., Naesens L. 2009. Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting. The Journal of Gene Medicine. John Wiley & Sons nr.11 , pp. 119-127 , ISSN 1099-498X

Camps P., Duque M., Vázquez S., Naesens L., De Clercq E., Sureda F., López-Querol M., Camins A., Pallàs M., Prathalingam S., Kelly J., Romero V., Ivorra D., Cortés D. 2008. Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs. Bioorganic & Medicinal Chemistry. Pergamon nr.16 , pp. 9925-9936 , ISSN 0968-0896

Lenaerts L., De Clercq E., Naesens L. 2008. Clinical features and treatment of adenovirus infections. Reviews in Medical Virology. John Wiley and Sons nr.18 , pp. 357-374 , ISSN 1052-9276

Naesens L., Andrei G., Votruba I., Krečmerová M., Holý A., Neyts J., De Clercq E., Snoeck R. 2008. Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. Biochemical Pharmacology. Elsevier nr.76 , pp. 997-1005 , ISSN 0006-2952

de Castro S., Peromingo M., Naesens L., Andrei G., Snoeck R., Balzarini J., Velázquez S., Camarasa M. 2008. 4''-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action. Journal of Medicinal Chemistry. ACS Publications nr.51 , pp. 5823-5832 , ISSN 0022-2623

Camps P., Gómez T., Munoz-Torrero D., Rull J., Sánchez L., Boschi F., Comes-Franchini M., Ricci A., Calvet T., Font-Bardia M., De Clercq E., Naesens L. 2008. Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent. Journal of Organic Chemistry. American Chemical Society nr.73 , pp. 6657-6665 , ISSN 0022-3263

Zoidis G., Tsotinis A., Kolocouris N., Kelly J., Prathalingam S., Naesens L., De Clercq E. 2008. Design and synthesis of bioactive 1,2-annulated adamantane derivatives. Organic & Biomolecular Chemistry. Royal Society of Chemistry nr.6 , pp. 3177-3185 , ISSN 1477-0520

Gawin R., De Clercq E., Naesens L., Koszytkowska-Stawińska M. 2008. Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure. Bioorganic & Medicinal Chemistry. Pergamon nr.16 , pp. 8379-8389 , ISSN 0968-0896

Gazivoda T., Raić-Malić S., Kristafor V., Makuc D., Plavec J., Bratulić S., Kraljević-Pavelić S., Pavelić K., Naesens L., Andrei G., Snoeck R., Balzarini J., Mintas M. 2008. Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues. Bioorganic & Medicinal Chemistry. Pergamon nr.16 , pp. 5624-5634 , ISSN 0968-0896

Lenaerts L., Kelchtermans H., Geboes L., Matthys P., Verbeken E., De Clercq E., Naesens L. 2008. Recovery of humoral immunity is critical for successful antiviral therapy in disseminated mouse adenovirus type 1 infection. Antimicrobial Agents and Chemotherapy. American Society for Microbiology (ASM) nr.52 , pp. 1462-1471 , ISSN 0066-4804

Carrouée-Durantel S., Durantel D., Werle B., Pichoud C., Naesens L., Neyts J., Trépo C., Zoulim F. 2008. Suboptimal response to adefovir dipivoxil therapy for chronic hepatitis B in nucleoside-naive patients is not due to pre-existing drug resistance mutants. Antiviral Therapy. International Medical Press nr.13 , pp. 381-388 , ISSN 1359-6535

Bonnafous P., Boutolleau D., Naesens L., Deback C., Gautheret-Dejean A., Agut H. 2008. Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro selection. Antiviral Research. Elsevier/North-Holland nr.77 , pp. 237-240 , ISSN 0166-3542

McGuigan C., Pathirana R., Migliore M., Adak R., Luoni G., Jones A., Díez-Torrubia A., Camarasa M., Velázquez S., Henson G., Verbeken E., Sienaert R., Naesens L., Snoeck R., Andrei G., Balzarini J. 2007. Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus. The Journal of Antimicrobial Chemotherapy. Oxford University Press nr.60 , pp. 1316-1330 , ISSN 0305-7453

Krecmerová M., Holý A., Pohl R., Masojídková M., Andrei G., Naesens L., Neyts J., Balzarini J., De Clercq E., Snoeck R. 2007. Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity. Journal of Medicinal Chemistry. ACS Publications nr.50 , pp. 5765-5772 , ISSN 0022-2623

Krecmerová M., Holý A., Pískala A., Masojídková M., Andrei G., Naesens L., Neyts J., Balzarini J., De Clercq E., Snoeck R. 2007. Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry. ACS Publications nr.50 , pp. 1069-1077 , ISSN 0022-2623

Etheve-Quelquejeu M., Tranchier J., Rose-Munch F., Rose E., Naesens L., De Clercq E. 2007. eta(6)-(Arene)tricarbonylehromium and manganese complexes linked to 2 '-deoxyuridine. Organometallics. American Chemical Society (WASHINGTON) nr.26 , pp. 5727-5730 , ISSN 0276-7333

Kolocouris N., Zoidis G., Foscolos G., Fytas G., Prathalingham S., Kelly J., Naesens L., De Clercq E. 2007. Design and synthesis of bioactive adamantane spiro heterocycles. Bioorganic & Medicinal Chemistry Letters. Pergamon Press (OXFORD) nr.17 , pp. 4358-4362 , ISSN 0960-894X

Bonnafous P., Naesens L., Petrella S., Gautheret-Dejean A., Boutolleau D., Sougakoff W., Agut H. 2007. Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet. Antiviral Therapy. International Medical Press (LONDON) nr.12 , pp. 877-888 , ISSN 1359-6535

De Clercq E., Naesens L. 2006. In search of effective anti-HHV-6 agents. Journal of Clinical Virology. Elsevier Science nr.37 Suppl 1 , pp. S82-S86 , ISSN 1386-6532

Naesens L., Bonnafous P., Agut H., De Clercq E. 2006. Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts. Journal of Clinical Virology. Elsevier Science nr.37 Suppl 1 , pp. S69-S75 , ISSN 1386-6532

Naesens L., Stephens C., Andrei G., Loregian A., De Bolle L., Snoeck R., Sowell J., De Clercq E. 2006. Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses. Antiviral Research. Elsevier/North-Holland nr.72 , pp. 60-67 , ISSN 0166-3542

Lenaerts L., Naesens L. 2006. Antiviral therapy for adenovirus infections. Antiviral Research. Elsevier/North-Holland nr.71 , pp. 172-180 , ISSN 0166-3542

Lenaerts L., Daelemans D., Geukens N., De Clercq E., Naesens L. 2006. Mouse adenovirus type 1 attachment is not mediated by the coxsackie-adenovirus receptor. FEBS Letters. Elsevier on behalf of the Federation of European Biochemical Societies nr.580 , pp. 3937-3942 , ISSN 0014-5793

Zoidis G., Fytas C., Papanastasiou I., Foscolos G., Padalko E., De Clercq E., Naesens L., Neyts J., Kolocouris N. 2006. Heterocyclic rimantadine analogues with antiviral activity. Bioorganic & Medicinal Chemistry. Pergamon nr.14 , pp. 3341-3348 , ISSN 0968-0896

Stittelaar K., Neyts J., Naesens L., van Amerongen G., van Lavieren R., Holý A., De Clercq E., Niesters H., Fries E., Maas C., Mulder P., van der Zeijst B., Osterhaus A. 2006. Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature. nr.439 , pp. 745-748 , ISSN 0028-0836

Lenaerts L., Verbeken E., De Clercq E., Naesens L. 2005. Mouse adenovirus type 1 infection in SCID mice: an experimental model for antiviral therapy of systemic adenovirus infections. Antimicrobial Agents and Chemotherapy. American Society for Microbiology (ASM) nr.49 , pp. 4689-4699 , ISSN 0066-4804

Kuypers D., Vandooren A., Lerut E., Evenepoel P., Claes K., Snoeck R., Naesens L., Vanrenterghem Y. 2005. Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients. American Journal of Transplantation. Munksgaard International Publishers nr.5 , pp. 1997-2004 , ISSN 1600-6135

Naesens L., Lenaerts L., Andrei G., Snoeck R., Van Beers D., Holy A., Balzarini J., De Clercq E. 2005. Antiadenovirus activities of several classes of nucleoside and nucleotide analogues. Antimicrobial Agents and Chemotherapy. American Society for Microbiology (ASM) nr.49 , pp. 1010-1016 , ISSN 0066-4804

de Bilderling G., Bodart E., Lawson G., Tuerlinckx D., Remacle M., Naesens L., De Clercq E., Snoeck R. 2005. Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis. Journal of Medical Virology. Wiley-Liss nr.75 , pp. 332-335 , ISSN 0146-6615

De Bolle L., Naesens L., De Clercq E. 2005. Update on human herpesvirus 6 biology, clinical features, and therapy. Clinical Microbiology Reviews. American Society for Microbiology (ASM) nr.18 , pp. 217-245 , ISSN 0893-8512

De Clercq E., Andrei G., Balzarini J., Leyssen P., Naesens L., Neyts J., Pannecouque C., Snoeck R., Ying C., Hocková D., Holý A. 2005. Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines. XV International Round Table on "Nucleosides, Nucleotides and Their Biological Applications". Minneapolis, Minnesota, USA, 12-16 September 2004Marcel Dekker nr.24 , pp. 331-341 , ISSN 1525-7770

De Bolle L., van Loon J., De Clercq E., Naesens L. 2004. Quantitative analysis of human herpesvirus 6 cell tropism. Journal of medical virology. nr.75 , pp. 76-85 , ISSN 0146-6615

De Bolle L., Manichanh C., Agut H., De Clercq E., Naesens L. 2004. Human herpesvirus 6 DNA polymerase: enzymatic parameters, sensitivity to ganciclovir and determination of the role of the A961V mutation in HHV-6 ganciclovir resistance. Antiviral research. nr.64 , pp. 17-25 , ISSN 0166-3542

Balzarini J., Pannecouque C., Naesens L., Andrei G., Snoeck R., De Clercq E., Hocková D., Holý A. 2004. 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity. Joint 9th European/11th International Meeting on Purines and Pyrimidines. Amsterdam, The Netherlands, 2003Marcel Dekker nr.23 , pp. 1321-1327 , ISSN 1525-7770

De Bolle L., Hatse S., Verbeken E., De Clercq E., Naesens L. 2004. Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle. FEBS Letters. nr.560 , pp. 25-9 , ISSN 0014-5793

De Bolle L., Andrei G., Snoeck R., Zhang Y., Van Lommel A., Otto M., Bousseau A., Roy C., De Clercq E., Naesens L. 2004. Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423. Biochemical Pharmacology. nr.67 , pp. 325-36 , ISSN 0006-2952

De Bolle L., Balzarini J., De Clercq E., Naesens L. 2003. Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay. XV International Round Table on "Nucleosides, Nucleotides and Their Biological Applications". Leuven, Belgium, 10-14 September 2002Marcel Dekker nr.22 , pp. 999-1001 , ISSN 1525-7770

Sienaert R., Naesens L., Brancale A., Carangio A., Andrei G., Snoeck R., Van Kuilenburg A., De Clercq E., McGuigan C., Balzarini J. 2003. Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV). XV International Round Table on "Nucleosides, Nucleotides and Their Biological Applications". Leuven, Belgium, 10-14 September 2002Marcel Dekker nr.22 , pp. 995-997 , ISSN 1525-7770

Muus U., De Clercq E., Balzarini J., Naesens L., Meier C. 2003. Study of different substituted cyclic and acyclic benzylpronucleotides of d4T relative to their hydrolytic stability and antiviral activity. XV International Round Table on "Nucleosides, Nucleotides and Their Biological Applications". Leuven, Belgium, 10-14 September 2002Marcel Dekker nr.22 , pp. 791-795 , ISSN 1525-7770

Snoeck R., Andrei G., Bodaghi B., Lagneaux L., Daelemans D., De Clercq E., Neyts J., Schols D., Naesens L., Michelson S., Bron D., Otto M., Bousseau A., Nemecek C., Roy C. 2002. 2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections. Antiviral research. nr.55 , pp. 413-24 , ISSN 0166-3542

De Bolle L., Michel D., Mertens T., Manichanh C., Agut H., De Clercq E., Naesens L. 2002. Role of the human herpesvirus 6 u69-encoded kinase in the phosphorylation of ganciclovir. Molecular Pharmacology. nr.62 , pp. 714-21 , ISSN 0026-895X

van Gelder J., Deferme S., Naesens L., De Clercq E., Van den Mooter G., Kinget R., Augustijns P. 2002. Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures. Drug metabolism and disposition: the biological fate of chemicals. nr.30 , pp. 924-930 , ISSN 0090-9556

Holý A., Votruba I., Masojídková M., Andrei G., Snoeck R., Naesens L., De Clercq E., Balzarini J. 2002. 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry. nr.45 , pp. 1918-1929 , ISSN 0022-2623

Deferme S., Van Gelder J., Ingels F., Van den Mooter G., De Buck S., Balzarini J., Naesens L., De Clercq E., Kinget R., Augustijns P. 2002. Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781. International journal of pharmaceutics. nr.234 , pp. 113-119 , ISSN 0378-5173

Ducho C., Balzarini J., Naesens L., De Clercq E., Meier C. 2002. Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity. Antiviral chemistry & chemotherapy. nr.13 , pp. 129-41 , ISSN 0956-3202

Meier C., Muus U., Renze J., Naesens L., De Clercq E., Balzarini J. 2002. Comparative study of bis(benzyl)phosphate triesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and cyclosal-d4TMP--hydrolysis, mechanistic insights and anti-HIV activity. Antiviral chemistry & chemotherapy. nr.13 , pp. 101-14 , ISSN 0956-3202

Sienaert R., Naesens L., Brancale A., De Clercq E., McGuigan C., Balzarini J. 2002. Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. Molecular Pharmacology. nr.61 , pp. 249-254 , ISSN 0026-895X

Sampath J., Adachi M., Hatse S., Naesens L., Balzarini J., Flatley R., Matherly L., Schuetz J. 2002. Role of MRP4 and MRP5 in biology and chemotherapy. AAPS pharmSci. nr.4 , pp. E14- , ISSN 1522-1059

Damian F., Blaton N., Desseyn H., Clou K., Augustijns P., Naesens L., Balzarini J., Kinget R., Van den Mooter G. 2001. Solid state properties of pure UC-781 and solid dispersions with polyvinylpyrrolidone (PVP K30). Journal of Pharmacy and Pharmacology. nr.53 , pp. 1109-1116 , ISSN 0022-3573

Naesens L., De Clercq E. 2001. Recent developments in herpesvirus therapy. Herpes : the journal of the IHMF. nr.8 , pp. 12-6 , ISSN 0969-7667

Neyts J., Naesens L., Ying C., De Bolle L., De Clercq E. 2001. Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo. Antiviral research. nr.49 , pp. 115-20 , ISSN 0166-3542

Damian F., Blaton N., Augustijns P., Naesens L., Balzarini J., Kinget R., Van den Mooter G. 2001. Thermal characterization of the antiviral drug UC-781 and stability of its glass. Thermochimica Acta. ELSEVIER SCIENCE BV nr.366 , pp. 61-69 , ISSN 0040-6031

De Clercq E., Naesens L., De Bolle L., Schols D., Zhang Y., Neyts J. 2001. Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. Reviews in medical virology. nr.11 , pp. 381-95 , ISSN 1052-9276

Chavalitshewinkoon-Petmitr P., Chawprom S., Naesens L., Balzarini J., Wilairat P. 2000. Partial purification and characterization of mitochondrial DNA polymerase from Plasmodium falciparum. Parasitology International. Elsevier nr.49 , pp. 279-288 , ISSN 1383-5769

Van Gelder J., Deferme S., Annaert P., Naesens L., De Clercq E., Van den Mooter G., Kinget R., Augustijns P. 2000. Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism. Drug metabolism and disposition: the biological fate of chemicals. nr.28 , pp. 1394-6 , ISSN 0090-9556

Annaert P., Tukker J., Van Gelder J., Naesens L., De Clercq E., Van den Mooter G., Kinget R., Augustijns P. 2000. In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil. Journal of pharmaceutical sciences. nr.89 , pp. 1054-1062 , ISSN 0022-3549

Damian F., Blaton N., Naesens L., Balzarini J., Kinget R., Augustijns P., Van den Mooter G. 2000. Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14. European journal of pharmaceutical sciences. nr.10 , pp. 311-322 , ISSN 0928-0987

Balzarini J., Naesens L., Aquaro S., Knispel T., Perno C., De Clercq E., Meier C. 1999. Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine). Molecular Pharmacology. nr.56 , pp. 1354-61 , ISSN 0026-895X

Saboulard D., Naesens L., Cahard D., Salgado A., Pathirana R., Velazquez S., McGuigan C., De Clercq E., Balzarini J. 1999. Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine. Molecular Pharmacology. nr.56 , pp. 693-704 , ISSN 0026-895X

Van Gelder J., Witvrouw M., Pannecouque C., Henson G., Bridger G., Naesens L., De Clercq E., Annaert P., Shafiee M., Van den Mooter G., Kinget R., Augustijns P. 1999. Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA. International journal of pharmaceutics. nr.186 , pp. 127-136 , ISSN 0378-5173

Van Gelder J., Annaert P., Naesens L., De Clercq E., Van den Mooter G., Kinget R., Augustijns P. 1999. Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study. Pharmaceutical Research. Kluwer academic/Plenum publishing corporation nr.16 , pp. 1035-1040 , ISSN 0724-8741

Smeijsters L., Franssen F., Naesens L., de Vries E., Holý A., Balzarini J., De Clercq E., Overdulve J. 1999. Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates. International journal of antimicrobial agents. nr.12 , pp. 53-61 , ISSN 0924-8579

Naesens L., Hatse S., Segers C., Verbeken E., De Clercq E., Waer M., Balzarini J. 1999. 9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats. Oncology research. nr.11 , pp. 195-203 , ISSN 0965-0407

Van den Mooter G., Stas G., Damian F., Naesens L., Balzarini J., Kinget R., Augustijns P. 1998. Stability of UC-781, in intestinal mucosal homogenates of the rat, rabbit, and pig. Pharmaceutical Research. nr.15 , pp. 1799-1802 , ISSN 0724-8741

Hatse S., Naesens L., De Clercq E., Balzarini J. 1998. Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model. Biochemical Pharmacology. nr.56 , pp. 851-9 , ISSN 0006-2952

Balzarini J., Naesens L., De Clercq E. 1998. New antivirals - mechanism of action and resistance development. Current opinion in microbiology. nr.1 , pp. 535-46 , ISSN 1369-5274

Annaert P., Van Gelder J., Naesens L., De Clercq E., Van den Mooter G., Kinget R., Augustijns P. 1998. Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers. Pharmaceutical Research. Plenum publishing corporation nr.15 , pp. 1168-1173 , ISSN 0724-8741

Hatse S., Naesens L., Degrève B., Vandeputte M., Waer M., De Clercq E., Balzarini J. 1998. In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma. Proceedings of the 9th International/6th Eropean Joint Symposium on Purine & Pyrimidine Metabolism in Man. Gmunden, Austria, 1-7 June 1997 nr.431 , pp. 605-9 , ISSN 0065-2598

Naesens L., Bischofberger N., Augustijns P., Annaert P., Van den Mooter G., Arimilli M., Kim C., De Clercq E. 1998. Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice. Antimicrobial Agents and Chemotherapy. nr.42 , pp. 1568-1573 , ISSN 0066-4804

Balzarini J., Naesens L., Verbeken E., Laga M., Van Damme L., Parniak M., Van Mellaert L., Anné J., De Clercq E. 1998. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS. Gower Academic Journals nr.12 , pp. 1129-38 , ISSN 0269-9370

Hatse S., Naesens L., Degrève B., Segers C., Vandeputte M., Waer M., De Clercq E., Balzarini J. 1998. Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats. International Journal of Cancer. nr.76 , pp. 595-600 , ISSN 0020-7136

Thormar H., Georgsson G., Gunnarsson E., Naesens L., Torsteinsdóttir S., Balzarini J., De Clercq E. 1998. Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA). Antiviral chemistry & chemotherapy. nr.9 , pp. 245-52 , ISSN 0956-3202

Balzarini J., Hatse S., Naesens L., De Clercq E. 1998. Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA). Biochimica et Biophysica Acta. Molecular Cell Research. Elsevier nr.1402 , pp. 29-38 , ISSN 0167-4889

Snoeck R., Wellens W., Desloovere C., Van Ranst M., Naesens L., De Clercq E., Feenstra L. 1998. Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine]. Journal of medical virology. nr.54 , pp. 219-225 , ISSN 0146-6615

Annaert P., Gosselin G., Pompon A., Benzaria S., Valette G., Imbach J., Naesens L., Hatse S., De Clercq E., Van den Mooter G., Kinget R., Augustijns P. 1998. Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers. Pharmaceutical Research. Plenum publishing corporation nr.15 , pp. 239-245 , ISSN 0724-8741

Hartmann K., Kuffer M., Balzarini J., Naesens L., Goldberg M., Erfle V., Goebel F., De Clercq E., Jindrich J., Holy A., Bischofberger N., Kraft W. 1998. Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes. Lippincott Williams & Wilkins nr.17 , pp. 120-8 , ISSN 1525-4135

De Groote K., Naesens L., Balzarini J., Baes M., Declercq P. 1997. Effects of 2',3'-dideoxycytidine and 2',3'-dideoxycytidine 5'-triphosphate on phospholipid metabolism in permeabilized rat hepatocytes. Biochemical Pharmacology. nr.54 , pp. 713-9 , ISSN 0006-2952

McGuigan C., Tsang H., Cahard D., Turner K., Velazquez S., Salgado A., Bidois L., Naesens L., De Clercq E., Balzarini J. 1997. Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation. Antiviral research. nr.35 , pp. 195-204 , ISSN 0166-3542

Balzarini J., Kruining J., Wedgwood O., Pannecouque C., Aquaro S., Perno C., Naesens L., Witvrouw M., Heijtink R., De Clercq E., McGuigan C. 1997. Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Letters. nr.410 , pp. 324-8 , ISSN 0014-5793

Annaert P., Kinget R., Naesens L., De Clercq E., Augustijns P. 1997. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2). Pharmaceutical Research. Plenum publishing corporation nr.14 , pp. 492-496 , ISSN 0724-8741

Naesens L., Snoeck R., Andrei G., Balzarini J., Neyts J., De Clercq E. 1997. HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: a review of their pharmacology and clinical potential in the treatment of viral infections. Antiviral Chemistry & Chemotherapy. Blackwell Scientific Publications nr.8 , pp. 1-23 , ISSN 0956-3202

Balzarini J., Karlsson A., Aquaro S., Perno C., Cahard D., Naesens L., De Clercq E., McGuigan C. 1996. Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives. Proceedings of the National Academy of Sciences of the United States of America. nr.93 , pp. 7295-9 , ISSN 0027-8424

Naesens L., Balzarini J., Bischofberger N., De Clercq E. 1996. Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. Antimicrobial Agents and Chemotherapy. nr.40 , pp. 22-8 , ISSN 0066-4804

Reymen D., Naesens L., Balzarini J., Holý A., Dvoráková H., De Clercq E. 1995. Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. Antiviral research. nr.28 , pp. 343-57 , ISSN 0166-3542

Thormar H., Georgsson G., Pálsson P., Balzarini J., Naesens L., Torsteinsdóttir S., De Clercq E. 1995. Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs. Proceedings of the National Academy of Sciences of the United States of America. nr.92 , pp. 3283-7 , ISSN 0027-8424

Vahlenkamp T., De Ronde A., Balzarini J., Naesens L., De Clercq E., van Eijk M., Horzinek M., Egberink H. 1995. (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection. Antimicrobial Agents and Chemotherapy. nr.39 , pp. 746-9 , ISSN 0066-4804

Naesens L., Balzarini J., De Clercq E. 1995. The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents. Advances in Biochemistry (Postepy biochemii). nr.41 , pp. 347-51 , ISSN 0032-5422

Naesens L., Neyts J., Balzarini J., Bischofberger N., De Clercq E. 1995. In vivo antiretroviral efficacy of oral Bis(POM)-PMEA, the bis(pivaloyloxymethyl)prodrug of 9-(2-phosphonylmethoxyethyl)adenine (PMEA). Nucleosides & Nucleotides. M. Dekker nr.14 , pp. 767-77 , ISSN 0732-8311

Naesens L., Balzarini J., De Clercq E. 1994. Therapeutic potential of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) as an antiviral drug. Reviews in Medical Virology. John Wiley and Sons nr.4 , pp. 147-59 , ISSN 1052-9276

Otake T., Schols D., Witvrouw M., Naesens L., Nakashima H., Moriya T., Kurita H., Matsumoto K., Ueba N., De Clercq E. 1994. Modified cyclodextrin sulphates (mCDS11) have potent inhibitory activity against HIV and high oral bioavailability. Antiviral Chemistry & Chemotherapy. Blackwell Scientific Publications nr.5 , pp. 155-161 , ISSN 0956-3202

Balzarini J., Naesens L., Bohman C., Pérez-Pérez M., San-Félix A., Camarasa M., De Clercq E. 1993. Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N- methyl-thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dio xide). Biochemical Pharmacology. nr.46 , pp. 69-77 , ISSN 0006-2952

Naesens L., Neyts J., Balzarini J., Holý A., Rosenberg I., De Clercq E. 1993. Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice. Journal of medical virology. nr.39 , pp. 167-72 , ISSN 0146-6615

Balzarini J., Holý A., Jindrich J., Naesens L., Snoeck R., Schols D., De Clercq E. 1993. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrobial Agents and Chemotherapy. nr.37 , pp. 332-8 , ISSN 0066-4804

Naesens L., Balzarini J., De Clercq E. 1992. Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine. Drug metabolism and disposition: the biological fate of chemicals. nr.20 , pp. 747-52 , ISSN 0090-9556

Naesens L., Balzarini J., De Clercq E. 1992. Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection. Clinical Chemistry. nr.38 , pp. 480-5 , ISSN 0009-9147

Balzarini J., Naesens L., Slachmuylders J., Niphuis H., Rosenberg I., Holý A., Schellekens H., De Clercq E. 1991. 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. AIDS. Gower Academic Journals nr.5 , pp. 21-8 , ISSN 0269-9370

Balzarini J., Naesens L., De Clercq E. 1990. Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered. International Journal of Cancer. nr.46 , pp. 337-40 , ISSN 0020-7136

Balzarini J., Sobis H., Naesens L., Vandeputte M., De Clercq E. 1990. Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus. International Journal of Cancer. nr.45 , pp. 486-9 , ISSN 0020-7136

Balzarini J., Naesens L., Robins M., De Clercq E. 1990. Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside. Journal of Acquired Immune Deficiency Syndromes. Lippincott Williams & Wilkins nr.3 , pp. 1140-7 , ISSN 1525-4135

Naesens L., Balzarini J., Rosenberg I., Holý A., De Clercq E. 1989. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. European Journal of Clinical Microbiology & Infectious Diseases. nr.8 , pp. 1043-7 , ISSN 0934-9723

Balzarini J., Naesens L., Herdewijn P., Rosenberg I., Holý A., Pauwels R., Baba M., Johns D., De Clercq E. 1989. Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proceedings of the National Academy of Sciences of the United States of America. nr.86 , pp. 332-336 , ISSN 0027-8424

International conference papers (6)

De Clercq E., Andrei G., Snoeck R., De Bolle L., Naesens L., Degrève B., Balzarini J., Zhang Y., Schols D., Leyssen P., Ying C., Neyts J. 2001. Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents. In XIV International Round Table on "Nucleosides, Nucleotides and Their Biological Applications". San Francisco, CA, USA, 10-14 September 2000 nr.20 , pp. 271-85 , ISSN 1525-7770

De Clercq E., Andrei G., Balzarini J., Hatse S., Liekens S., Naesens L., Neyts J., Snoeck R. 1999. Antitumor potential of acyclic nucleoside phosphonates. In XIIIth International Round Table of Nucleosides, Nucleotides, and their Biological Applications. Montpellier, France, 6-10 September 1998 nr.18 , pp. 759-71 , ISSN 0732-8311

Naesens L., Cahard D., Salgado A., Bidois L., De Clercq E., McGuigan C., Balzarini J. 1998. Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety. In Proceedings of the 9th International/6th Eropean Joint Symposium on Purine & Pyrimidine Metabolism in Man. Gmunden, Austria, 1-7 June 1997 nr.431 , pp. 753-7 , ISSN 0065-2598

Balzarini J., Naesens L., Verbeken E., Laga M., Van Damme L., Verstraeten M., Van Mellaert L., Anné J., De Clercq E. 1998. The thiocarboxanilide UC-781 is a potential virucidal drug. In 12th World AIDS Conference. Geneva, Switzerland, 28 June-3 July 1998Monduzzi Editore, Int. Proc. Div. (Bologna, Italy) , pp. 243-7

Wellens W., Snoeck R., De Sloovere C., Van Ranst M., Naesens L., De Clercq E., Feenstra L. 1997. Treatment of severe laryngeal papillomatosis with intralesional injections of Cidofovir R [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC, Vistide R],. In Word Congress of Otorhinolaryngology Head and Neck Surgery. McCafferty G., Coman W., Carroll R. (eds.) Sydney, Australia, 2-7 March 1997Monduzzi Editore (Bologna, Italy) , pp. 455-459

De Clercq E., Neyts J., Naesens L., Balzarini J. 1992. Therapeutic potential of acyclic nucleoside phosphonates in the treatment of herpes- and retrovirus infections (i.e. HPMPC against MCMV infection in SCID mice). In The Fifth International Antiviral Symposium and the Second Korean-American AIDS symposium. Seoul National University, Korea, 21-25 June 1992 , pp. 144-50

Talks at international conferences (44)

Stevaert A., Nurra S., Pala N., Carcelli M., Rogolino D., Sechi M., Naesens L. 2014. Optimized biological assays and pharmacophore searching for development of inhibitors of the influenza virus PA endonuclease. 3th Antiviral Congress. Amsterdam, The Netherlands, 12-14 October 2014

Stevaert A., Nurra S., Pala N., Carcelli M., Rogolino D., Knowlton C., Baek K., Alfonso-Prieto M., Marras S., Sechi M., Naesens L. 2014. Optimized biological assays and pharmacophore searching for development of inhibitors of the influenza virus PA endonuclease. 4th International Influenza Meeting. Münster, Germany, 21-23 September 2014

Vrijens P., Vanstreels E., Noppen S., Vanderlinden E., Stevaert A., Liekens S., Daelemans D., Naesens L. 2014. Towards a better understanding of influenza virus nucleoprotein phosphorylation and its role in virus replication. 4th International Influenza Meeting. Münster, Germany, 21-23 September 2014

Pala N., Dallocchio R., Dessì A., Cadoni R., Carcelli M., Stevaert A., Sechi M., Naesens L. 2014. Virtual screening and in-vitro validation of novel inhibitors of influenza virus PA endonuclease. 2nd Innovative Approaches for Identification of Antiviral Agents Summer School. Cagliari, Sardinia, Italy, 28 September-3 October 2014

Nurra S., Pala N., Carcelli M., Rogolino D., Stevaert A., Sechi M., Naesens L. 2014. Searching for the pharmacophore in β-diketo acid inhibitors of influenza virus PA endonuclease. 8th Nuove Prospettive in Chimica Farmaceutica. Parma, Italy, 9-11 June 2014

Zoidis G., Giannakopoulou E., Stevaert A., Myrianthopoulos V., Fytas G., Mikros E., Naesens L. 2013. Novel flutimide analogues targeting the influenza virus PA endonuclease. 5th BBBB International Conference. Athens, Greece, 26-28 September 2013

Vanderlinden E., Meneghesso S., Brancale A., Balzarini J., McGuigan C., Naesens L. 2013. 2’-Fluoro-2’-deoxypurineriboside ProTides: a step forward towards developing influenza virus polymerase inhibitors. 15th International Conference on Negative Strand Viruses. Granada, Spain, 16-21 June 2013

Stevaert A., Dallocchio R., Dessì A., Pala N., Rogolino D., Sechi M., Naesens L. 2013. Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease. 15th International Negative Strand Virus Meeting. Granada, Spain, 16-21 June 2013

Zoidis G., Giannakopoulou E., Stevaert A., Myrianthopoulos V., Fytas G., Mikros E., Naesens L. 2013. Novel flutimide analogues targeting the influenza virus PA endonuclease. 16th Panhellenic Pharmaceutical Conference. Athens, Greece, 31 May-03 June 2013

Vanderlinden E., Meneghesso S., Brancale A., Balzarini J., McGuigan C., Naesens L. 2013. 2'-Fluoro-2'-deoxypurineriboside ProTides: a step forward towards developing influenza virus polymerase inhibitors. 26th International Conference on Antiviral Research. San Francisco, California, US, 11-15 May 2013

Stevaert A., Dallocchio R., Dessì A., Pala N., Rogolino D., Sechi M., Naesens L. 2013. Mutational analysis of the binding pocket of diketoacid L-742,001 in the influenza PA endonuclease. 26th International Conference on Antiviral Research. San Francisco, California, USA, 11-15 May 2013

Zoidis G., Giannakopoulou E., Stevaert A., Myrianthopoulos V., Fytas G., Mikros E., Naesens L. 2013. Novel flutimide analogues targeting the influenza virus PA endonuclease. 5th International Symposium on Advances in Synthetic and Medicinal Chemistry. Moscow, Russia, 5-8 May 2013

Vanderlinden E., Meneghesso S., Balzarini J., McGuigan C., Naesens L. 2012. Anti-influenza virus activity of nucleoside inhibitors of the influenza virus polymerase. 3rd International Influenza Meeting. Münster, Germany, 2-4 September 2012

Stevaert A., Rispoli G., Pala N., Marras S., Sechi M., Naesens L. 2012. Evaluation of influenza virus endonuclease inhibitors by cell culture and enzymatic methods, including a novel real-time fluorescence assay. 25th International Conference on Antiviral Research. Sapporo, Japan, 16-19 April 2012

Naesens L., Andrei G., Snoeck R., Gerry D., Banning J., Wilkerson P., Renew Z., Stephens C. 2011. Identification of bicyclic sulfone inhibitors of HHV-6 targeting the HHV-6 U77 helicase. 24th International Conference on Antiviral Research. Sofia, Bulgaria, 8-11 May 2011 nr.90

Vanderlinden E., Vanstreels E., Vermeire K., Daelemans D., Herczegh P., Sztaricskai F., Naesens L. 2011. Mechanistic studies on a novel hydrophobic derivative of aglycoristocetin with potent and broad activity against influenza viruses. 24nd International Conference on Antiviral Research. Sofia, Bulgaria, 8-11 May 2011Elsevier science bv nr.90 , ISSN 0166-3542

Zhan P., Chen X., Liu X., Pannecouque C., Naesens L., De Clercq E., Liu A., Du G. 2011. Thiazolylthioacetamides as a novel class of potential antiviral agents. 24th International Conference on Antiviral Research. Sofia, Bulgaria, 8-11 May 2011 nr.90

Meneghesso S., McGuigan C., Naesens L., Balzarini J., Vanderlinden E. 2011. Phosphoramidate Pro Tide technology applied to purine 2 '-deoxy-2 '-fluororibosides: Design, synthesis and biological evaluation. 241st National Meeting and Exposition of the American-Chemical-Society (ACS) Anaheim, CA, MAR 27-31, 2011. Amer chemical soc (1155 16TH ST, NW, WASHINGTON, DC 20036 USA) nr.241 , ISSN 0065-7727

Meneghesso S., McGuigan C., Naesens L., Balzarini J., Vanderlinden E. 2011. Design, synthesis and biological evaluation of uridine analogs as phosphate prodrugs. 241st National Meeting and Exposition of the American-Chemical-Society (ACS) Anaheim, CA, MAR 27-31, 2011. Amer chemical soc (1155 16TH ST, NW, WASHINGTON, DC 20036 USA) nr.241 , ISSN 0065-7727

Vanderlinden E., Roth E., Jeko J., Vanstreels E., Daelemans D., Illyés E., Batta G., Herczegh P., Sztaricskai F., Naesens L. 2010. Structure-activity relationship and mechanistic studies of a novel class of aglycoristocetin derivatives with potent and broad activity against influenza viruses. 2nd International Influenza Meeting. Münster, Germany, 12-14 September 2010

Vanderlinden E., Roth E., Jeko J., Andrei G., Snoeck R., Illyés E., Batta G., Herczegh P., Sztaricskai F., Naesens L. 2010. Structure-activity relationship and mechanistic studies of a novel class of aglycoristocetin derivatives with potent and broad activity against influenza virus. 14th International Conference on Negative Strand Viruses. Brugge, Belgium, 21-25 June 2010

Krecmerova M., Holy A., Andrei G., Pomeisl K., Tichy T., Laflamme G., Naesens L., Cihlar T., Neyts J., De Clercq E., Balzarini J., Snoeck R. 2010. Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. 23rd International Conference on Antiviral Research. San Francisco, CA, USA, 25-28 April 2010Elsevier/North-Holland nr.86

Vanderlinden E., Cesur N., Cesur Z., Goktas F., Froeyen M., Russell C., Reed M., Naesens L. 2009. Identification and mechanism of action of a novel class of influenza virus fusion inhibitors. 5th Orthomyxovirus Research Conference. Freiburg, Germany, 9-12 September 2009

Vanderlinden E., Cesur N., Cesur Z., Goktas F., Froeyen M., Russell C., Naesens L. 2009. Identification and Mechanistic Studies on a Novel Class of Influenza Virus Fusion Inhibitors. 22nd International Conference on Antiviral Research. Miami Beach, Florida, USA, 3-7 May 2009Elsevier science bv nr.82 , ISSN 0166-3542

Naesens L., Vanderlinden E., Roth E., Jeko J., Andrei G., Snoeck R., Pannecouque C., Illyes E., Batta G., Herczegh P., Sztaricskai F. 2009. Structure-activity relationship of a novel class of Aglycoristocetin derivatives with potent and broad activity against influenza viruses. 22nd International Conference on Antiviral Research. Miami Beach, Florida, USA, 3-7 May 2009Elsevier science bv nr.82 , ISSN 0166-3542

Krecmerová M., Holý A., Andrei G., Naesens L., Neyts J., Balzarini J., De Clercq E., Snoeck R. 2008. Synthesis and antiviral activity of various N4-acyl derivatives of cidofovir and its 5-azacytosine counterpart, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. 21th International Conference on Antiviral Research. Montreal, Quebec, Canada, 13-17 April 2008 nr.78

Vanderlinden E., Cesur N., Cesur Z., Goktas F., Naesens L. 2008. Identification and mode of action studies on novel inhibitors of influenza virus fusion. ICAV Sixth International Symposium. Toronto, Canada, 4-6 May 2008

Krecmerova M., Holy A., Piskala A., Andrei G., Snoeck R., Naesens L., Neyts J., Balzarini J., De Clercq E. 2007. Synthesis and antiviral activity of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine and its ester prodrugs. 20th International Conference on Antiviral Research. Palm Springs, CA, USA, 29 April-3 May 2007Elsevier science bv , ISSN 0166-3542

Naesens L., Andrei G., Votruba I., Krecmerova M., Holy A., Balzarini J., De Clercq E., Snoeck R. 2007. Chemical stability and intracellular metabolism of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. 20th International Conference on Antiviral Research. Palm Springs, CA, USA, 29 April-3 May 2007Elsevier science bv , ISSN 0166-3542

Andrei G., Krecmerova M., Holy A., Naesens L., Neyts J., Balzarini J., De Clercq E., Snoeck R. 2007. In vivo antiviral activity of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine and its cyclic form. 20th International Conference on Antiviral Research. Palm Springs, CA, USA, 29 April-3 May 2007Elsevier science bv , ISSN 0166-3542

Lenaerts L., Baker A., McVey J., Waddington E., Verbeken E., Naesens L. 2007. Effect of coagulation factors on liver targeting of mouse adenovirus type 1. 15th Annual Congress of the European Society of Gene Therapy. Rotterdam, The Netherlands, 27-30 October 2007

Lenaerts L., Verbeken E., De Clercq E., Naesens L. 2006. Mouse models for the evaluation of antiviral and immunotherapy in the treatment of systemic adenovirus infections. 14th International Symposium of Infections in the Immunocompromised Host. Crans-Montana, Switzerland, 2-5 July 2006Decker

Naesens L., Lenaerts L., Verbeken E., De Clercq E. 2005. Mouse adenovirus type 1-infected SCID mice: a unique model for the evaluation of antiviral compounds against systemic adenovirus infections. 18th International Conference on Antiviral Research. Barcelona, Spain, 11-14 April 2005 nr.65

Lenaerts L., Verbeken E., De Clercq E., Naesens L. 2005. Mouse adenovirus type 1-infected SCID mice: a unique model for the evaluation of antiviral compounds against systemic adenovirus infections. 156th meeting Society for General Microbiology. Edinburgh, Scotland, UK, 4-7 April 2005

Lenaerts L., Daelemans D., Geukens N., De Clercq E., Naesens L. 2005. Mouse Adenovirus Type 1 Attachment is not mediated by the Coxsackie-Adenovirus Receptor. 13th Annual Congress of the European Society of Gene Therapy. Prague, Czech Republic, 29 Oct - 1 Nov 2005

De Clercq E., Andrei G., Balzarini J., Leyssen P., Naesens L., Neyts J., Pannecouque C., Snoeck R., Ying C., Hocková D., Holý A. 2004. Antiviral potential of “new” acyclic nucleoside phosphonates, the 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines. XVII International Round Table on Nucleosides, Nucleotides and Nucleic Acids. Minneapolis, Minnesota, USA, 12-16 September 2004

Naesens L., Lenaerts L., Holý A., Balzarini J., De Clercq E. 2004. Activity of different classes of nucleoside and nucleotide analogues against adenovirus in cell culture. 17th International Conference on Antiviral Research. Tucson, Arizona, USA, 2-6 May 2004 nr.62

Sienaert R., Naesens L., Luoni G., Wathen M., Gray W., Andrei G., Snoeck R., De Clercq E., McGuigan C., Balzarini J. 2003. Interaction of the bicyclic nucleoside analogues (BCNAs) with human varicella-zoster virus (VZV) and simian varicella virus (SVV) thymidine kinase and VZV DNA polymerase. 16th International Conference on Antiviral Research. Savannah, Georgia, USA, 27 April-1 May 2003Elsevier science bv , ISSN 0166-3542

De Bolle L., Andrei G., Snoeck R., Van Lommel A., Otto M., Bousseau A., Roy C., De Clercq E., Naesens L. 2003. CMV423, a potent and selective inhibitor of human herpesvirus 6 exerts its antiviral action through inhibition of cellular protein tyrosine kinase activity. 16th International Conference on Antiviral Research. Savannah, Georgia, USA, 27 April-1 May 2003Elsevier science bv , ISSN 0166-3542

Balzarini J., Pannecouque C., Naesens L., Andrei G., Snoeck R., De Clercq E., Aquaro S., Perno C., Egberink H., Votruba I., Holý A. 2003. 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity. Joint 11th International and 9th European Symposium on Purines and Pyrimidines in Man. Egmond aan Zee, The Netherlands, 9-13 June 2003

Andrei G., Sienaert R., Naesens L., De Clercq E., McGuigan C., Balzarini J., Snoeck R. 2002. Susceptibilities of several drug-resistant varicella-zoster virus (VZV) strains to bicyclic pyrimidine nucleoside analogues (BCNAs). 15th International Conference on Antiviral Research. Prague, Czech Republic, 17-21 March 2002Elsevier science bv nr.53 , ISSN 0166-3542

Balzarini J., Sienaert R., Naesens L., Andrei G., Snoeck R., Van Kuilenburg A., Brancale A., De Clercq E., McGuigan C. 2002. Pharmacological properties of the novel anti-varicella-zoster virus bicyclic nucleoside analogues (BCNAs). 15th International Conference on Antiviral Research. Prague, Czech Republic, 17-21 March 2002Elsevier science bv , ISSN 0166-3542

Naesens L., De Bolle L., Andrei G., Snoeck R., Roy C., Nemecek C., Otto M., De Clercq E. 2000. Antiviral activity of the non-nucleoside analogue CMV423 in lymphoblast cells infected with human herpesvirus 6. Thirteenth International Conference on Antiviral Research. Baltimore, Maryland, USA, 16-21 April 2000Elsevier science bv , ISSN 0166-3542

Van Gelder J., Deferme S., Annaert P., Naesens L., De Clercq E., Van den Mooter G., Kinget R., Augustijns P. 1999. Inhibition of intestinal metabolism of the antiviral ester prodrug Bis(POC)-PMPA by strawberry extract results in an increase of its intestinal absorption in rat ileum. AAPS Annual Meeting and Exposition. New Orleans, November 14-18, 1999 nr.1

Doctoral theses (3)

Vanderlinden E. 2012. Emerging options for interfering with influenza virus entry and replication. Naesens L., Balzarini J. (sup.)

Lenaerts L. 2008. Mouse adenovirus as a model for adenovirus pathogenesis and tropism. Naesens L., De Clercq E. (sup.)

Various (1)

Balzarini J., Andrei G., Naesens L., Neyts J., Pannecouque C., Schols D., Snoeck R. 2006. Introduction to the special issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven (Editorial). Antiviral Research. Elsevier/North-Holland nr.71 , ISSN 0166-3542